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Glyceryl Trinitrate

About Glyceryl Trinitrate

Glyceryl Trinitrate is primarily indicated in preventing attacks of angina (chest pain) and treating angina due to coronary artery disease. Angina occurs when the heart does not receive sufficient oxygen.

Glyceryl Trinitrate contains Glyceryl Trinitrate, which works by relaxing blood vessels and reducing the heart's oxygen demand.

Glyceryl Trinitrate may cause common side effects such as dry mouth, blurred vision, headache, dizziness, weakness, nausea and vomiting, sweating, paleness, fainting, and flushing (warm or red skin). Most of these side effects are temporary and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

You should not take Glyceryl Trinitrate if you are allergic to nitrates or any of its ingredients or are taking medication for hypertension, glaucoma, heart disease, erectile dysfunction, or anemia. Check with your doctor if you're pregnant, currently breastfeeding or taking any other prescribed or non-prescribed medicines.

Uses of Glyceryl Trinitrate

Treatment of Angina (heart-related chest pain).

Medicinal Benefits

  • Provides fast relief from chest pain caused by reduced blood flow to the heart.
  • Relaxes and widens blood vessels, allowing better circulation to the heart.
  • Decreases the pressure on the heart, making it easier for the heart to pump blood.
  • Can be used before physical activity to help prevent chest pain episodes.
  • Sublingual tablets work quickly because they are absorbed directly under the tongue.

Directions for Use

  • Glyceryl Trinitrate can be taken with or without food.
  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Place Glyceryl Trinitrate below the tongue and allow it to dissolve without swallowing.
  • Do not swallow Glyceryl Trinitrate as a whole directly. It is also advised not to chew or crush Glyceryl Trinitrate.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Glyceryl Trinitrate

  • Dry mouth
  • Blurred vision
  • Insomnia
  • Headache
  • Vertigo/dizziness
  • Weakness
  • Heart palpitations
  • Low blood pressure upon rising from a seated position
  • Nausea
  • Vomiting
  • Sweating
  • Paleness
  • Fainting
  • Flushing

Drug Warnings

  • Do not take Glyceryl Trinitrate if you are allergic to nitrates or any of its ingredients.
  • Inform your doctor about all other OTC medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take.
  • If you have a kidney, drink or have ever consumed large amounts of alcohol, have anaemia, or have a heart attack.
  • Glyceryl Trinitrate should be taken with caution and only if a doctor prescribes you.
  • Tell your doctor if you are pregnant or breastfeeding before starting Glyceryl Trinitrate as a dose adjustment may be required if the benefits outweigh the harm.
  • Glyceryl Trinitrate may cause dizziness, light-headedness, and fainting when you get up too quickly from a lying position, especially when you start taking Glyceryl Trinitrate, so please get up gradually.

Drug Interactions

Drug-Drug Interaction: Glyceryl Trinitrate may interact with certain medicines and increase side effects:

  • Erectile dysfunction medication (sildenafil, tadalafil)
    • Potential effect: May cause a rapid decrease in blood pressure
  • Antidepressants (amitriptyline)
    • Potential effect: May increase the risk of low BP and lightheadedness.
  • Medicines used for High BP (atenolol, amlodipine)
    Potential effect: May enhance the BP-lowering effect.
  • Blood thinners (warfarin)
    • Potential effect: May increase the risk of bleeding.

Drug-Food Interaction: Limit alcohol consumption and drinks containing caffeine.

Drug-Disease Interaction: Inform your doctor if you have a history of the following conditions before taking Glyceryl Trinitrate, as it may worsen your condition or cause complications.

  • Myocardial infarction
  • Congestive heart failure
  • Anaemia
  • Hemodialysis (a procedure where a dialysis machine and a special filter called an artificial kidney)
  • Hypotension
  • Intracranial pressure
  • Pericarditis (inflammation of the pericardium)
  • Hypertrophic cardiomyopathy
  • Glaucoma.

Drug-Drug Interactions Checker List:

  • TADALAFIL
  • WARFARIN
  • SILDENAFIL
  • AMITRIPTYLINE
  • AMLODIPINE
  • ATENOLOL
  • Safety Advice

    • Safety Warning

      Alcohol

      unsafe

      Concomitant use of nitrates and alcohol may cause hypotension. So, the intake of Glyceryl Trinitrate should be avoided with Glyceryl Trinitrate.

    • Safety Warning

      Pregnancy

      consult your doctor

      Glyceryl Trinitrate is a pregnancy Category B medicine. It is not known whether Glyceryl Trinitrate will affect pregnant women or fetus or not. Hence, the intake of Glyceryl Trinitrate should be avoided if you are pregnant or planning to become pregnant, as it may harm the baby. Your doctor may give you if the benefits of Glyceryl Trinitrate outweigh the risks.

    • Safety Warning

      Breast Feeding

      consult your doctor

      The safety of Glyceryl Trinitrate is not known in breastfeeding women. So, Glyceryl Trinitrate should not be taken while breastfeeding.

    • Safety Warning

      Driving

      unsafe

      Glyceryl Trinitrate can affect alertness and coordination. So, operating machinery which requires concentration should be avoided.

    • Safety Warning

      Liver

      caution

      Glyceryl Trinitrate to be taken with caution, especially if you have a history of liver diseases. The dose may have to be adjusted by your doctor.

    • Safety Warning

      Kidney

      caution

      Glyceryl Trinitrate should be taken with caution, especially if you have a history of Kidney diseases. Your doctor may have to adjust the dose.

    • Safety Warning

      Children

      unsafe

      The safety and efficacy of Glyceryl Trinitrate in children have not been established. Glyceryl Trinitrate is not recommended in children unless given by a child specialist.

    Habit Forming

    No

    Diet & Lifestyle Advise

    Diet

    • Eat a heart-healthy diet with plenty of fruits, vegetables, and whole grains.
    • Reduce salt intake to help control blood pressure and protect heart health.
    • Limit fatty and fried foods to maintain healthy cholesterol levels.

    Lifestyle changes

    • Do moderate exercises such as walking or light stretching to maintain heart health.
    • Avoid heavy physical exertion that may trigger chest pain or angina.
    • Rest immediately if chest pain occurs and use the sublingual tablet as prescribed.
    • Consult your doctor before starting new exercises, especially if you have heart disease.

    Stress management

    • Practice relaxation techniques such as deep breathing or meditation to reduce stress.
    • Maintain regular sleep habits to support heart health and reduce anxiety.
    • Avoid emotional stress and overexertion, as they may trigger angina (chest pain).

    Habits

    • Avoid excessive alcohol and smoking, as it may increase dizziness and lower blood pressure.

    Special Advise

    • Certain diagnostic tests, such as a stress test, echocardiogram, nuclear stress test, Chest X-ray, Blood test, and Coronary angiography, help check for angina.
    • Regular checkups with the doctor as you may develop tolerance to Glyceryl Trinitrate, and the same dose may be less effective next time. Your doctor might increase your dose depending on your condition, and please stick to the dosage schedule.

    Patients Concern

    Disease/Condition Glossary

    Angina: It is a pain in the chest and discomfort that keeps coming back as the heart does not get sufficient blood. In some cases, the pain and discomfort are also felt in the shoulders, neck, jaw, or back. Angina is a symptom of coronary artery disease. Symptoms include squeezing, pressure, feeling of heaviness, tightness, and pain in the chest. Treatment includes lifestyle changes based on severity, angioplasty, surgery, or medications.

    FAQs

    Glyceryl Trinitrate is used in preventing attacks of angina (chest pain) and treatment of angina due to coronary artery disease.

    Glyceryl Trinitrate should not be taken before doing any physical workout to prevent angina pain. A person should consult with the doctor to know the right time of taking Glyceryl Trinitrate.

    Yes, Glyceryl Trinitrate can cause a headache. Please increase your fluid intake, as this is known to decrease headaches when taking Glyceryl Trinitrate. If the problem persists, consult your doctor and do as advised.

    Glyceryl Trinitrate is not advised in patients with severe anaemia, and one should tell their doctor if they have this condition.

    A person who is already taking phosphodiesterase type 5 (PDE-5) inhibitors, such as avanafil, sildenafil, tadalafil, or vardenafil, should not consume Glyceryl Trinitrate as it may cause serious side effects.

    If you miss a dose of Glyceryl Trinitrate, take the missed dose as soon as you remember it. However, if it is almost time for the next dose, do not take a double dose to make up for a missed one.

    It is suggested that you take Glyceryl Trinitrate in the dose and duration advised by your doctor. If you take it in more than the recommended dose, it might cause unpleasant side effects. If you think your symptoms are not improving, please consult your doctor.

    A person should not take Glyceryl Trinitrate with their erectile dysfunction medication as it might trigger the blood pressure-lowering effect of Glyceryl Trinitrate. Consult your doctor for further advice.

    A person should not stop taking Glyceryl Trinitrate without talking to their doctor. If they suddenly stop taking Glyceryl Trinitrate, they may experience confusion, fever, mental state changes, or severe muscle stiffness. Your doctor will probably decrease your dose gradually, depending upon your disease condition.

    Glyceryl Trinitrate should be kept in the original glass container and tightly capped after each use to prevent loss of tablet potency. Store Glyceryl Trinitrate tablets at room temperature.

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